Hamidun Bunawan Universiti Kebangsaan Malaysia
The skin is the body’s largest organ and is continuously exposed to environmental stressors, pathogenic microbes, and inflammatory triggers. Acne vulgaris, a common skin condition, is often treated with synthetic antibiotics, which may cause side effects and contribute to antibiotic resistance. This has led to a growing interest in natural alternatives, including probiotics. Lactobacillus species, especially Lactobacillus plantarum, have shown promise in promoting skin health due to their antimicrobial and immunomodulatory properties. The objectives of this study were to identify and characterise Lactobacillus plantarum F25 UKM, assess its antimicrobial properties, formulate a probiotic-infused soap, evaluate its physicochemical properties, and test its efficacy on acne-prone skin through a four-week human trial.The study successfully demonstrated that Lactobacillus plantarum F25 UKM has significant antimicrobial properties due to its production of bacteriocins. These compounds remained active within the formulated soap, suggesting that probiotic-derived actives can be preserved and delivered effectively through topical application. The reduction in acne lesions during the trial supports the use of probiotics as a sustainable and natural alternative to synthetic acne treatments.